CTRL + SPACE for auto-complete. These findings were recently presented at the European Society of Cardiology Annual Congress in Munich and published in the New England Journal of Medicine. Background and purpose: Although aspirin (acetylsalicylic acid) is commonly used to prevent ischaemic events in patients with coronary artery disease, many patients fail to respond to aspirin treatment. Learning Doesnt Have To Be Hard Heres How To Make It Easy. Prostaglandins Leukot Essent Fatty Acids. And that mineral oil raised a number of markers associated with cardiovascular risk, including the bad cholesterol, LDL, and a measure of inflammation C-reactive protein. Aspirin OK After Fracture to Help Avoid Blood Clots. Taking fish oil supplements with meals or freezing them can reduce these issues. 2015 Dec;136(6):1245-51. doi: 10.1016/j.thromres.2015.10.010. For better will not cause excessive bleeding , except 'couple of beers' ( what time interval every hr , every day or every month ? ) Studies show that aspirin can help prevent heart attacks and strokes caused by blood clots because it reduces your bloods ability to form clots. too much blood thinning? But please tell your doctor you're taking it. A combination of stable fish oil and aspirin thus improves the eicosanoid pattern more than aspirin alone. Its an individualized decision to make together with your health care provider.. Steven Nissen, MD: We have known for many years that for the vast majority who have suffered a previous heart attack or stroke, a daily Aspirin (or an alternative blood thinner for some) helps save lives and preserve your quality of life by helping to prevent future blood clots which can cause a second cardiovascular accident from occurring. Use of aspirin with beta-blockers can also potentially cause problems. Wearable Technology and Your Heart Health, Study Questions Fish Oil And Daily Aspirin In Healthy Diabetic Adults, Preparing for Your The second study tested daily use of fish oil supplements, which contain heart-healthy omega-3 fatty acids that have been shown to have protective effects on the heart. Steven Nissen, MD: Omega 3`s and low dose Aspirin work at different levels. This means, we need to ingest them through food or via a supplement, like fish oil! what was geralt's third wish in . But there is no substantial evidence that proves over-the-counter fish oil supplements can do any of those things. These have different effects. Seek your doctor's advice before taking any of these medications. Epub 2015 Apr 29. How long does it take for omega-3s to work? is it critical that low dose aspirin, fish oil, multivitamin, and vitamin c be discontinued 7 days in advance? If youre taking statin drugs and have muscle aches, the next step is talking to your doctor about changing your prescription.. PMC How does aspirin interact with fish oil? 70% of these people were satisfied with their results and will continue taking fish oil. Most products are made as softgels, which are usually made of . By using our website, you consent to our use of cookies. While fish oil is a general term for oils made from the tissue of fish, omega-3 describes a specific form of fatty acids, that are essential for our health and well-being but that our body cannot produce itself. 1. Omega 3`s replace cell products that release products of inflammation while the omega 3`s do You are 38 and pregnant. Fish oil side effects include heartburn, loose stools, and nosebleeds. Glucosamine, chondroitin, omega-3, and green tea are just a few of them. Talk to your doctor before using omega-3 polyunsaturated fatty acids together with aspirin. 2014. Unable to load your collection due to an error, Unable to load your delegates due to an error. We just concluded one of our major meetings of the year, the American College of Cardiology meeting, and there were several studies presented that are of considerable interest to patients. Having colonoscopy next week. At pennies a day, its one of the most effective ways of saving lives. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). So if you're having cardiac surgery, you may want to talk to your surgeon about whether occluding that left atrial appendage is a good idea. Reducing the possibility of having a first heart attack or stroke is called primary prevention. FOIA Omega-3 refers to omega-3 polyunsaturated fatty acids. 1996 Jun;54(6):419-25. doi: 10.1016/s0952-3278(96)90025-3. The Antiatherogenic Effect of Fish Oil in Male Mice Is Associated with a Diminished Release of Endothelial ADAM17 and ADAM10 Substrates. Before you use these medications in combination, you need to seek your doctor's advice and approval, according to the National Center for Biotechnology Information's PubMed Health. Please enable it to take advantage of the complete set of features! There is no established upper limit of omega-3 intake. Steven Nissen, MD: What they found was there was no difference in outcome. Capone ML, Sciulli MG, Tacconelli S, Grana M, Ricciotti E, Renda G, Di Gregorio P, Merciaro G, Patrignani P. J Am Coll Cardiol. DeFilippis AP, Rai SN, Cambon A, Miles RJ, Jaffe AS, Moser AB, Jones RO, Bolli R, Schulman SP. The effect of a combination of aspirin and fish oil on eicosanoids was studied. Before you use aspirin, you also need to speak with your doctor if you use other medications that can affect your cardiovascular health, include anticoagulants and ACE inhibitors. Consistently, a pro-resolution lipid mediator-Resolvin E1, was significantly elevated in plasma in FO/aspirin-treated mice. 2023 American College of Cardiology Foundation. The effect of a combination of aspirin and fish oil on eicosanoids was studied. Co-administration of FO and low-dose aspirin may act synergistically to protect against thrombosis and injury-induced vascular remodelling in mice. Announcer: However, theyre prescribed to help people with severe triglyceride disorders, not high cholesterol. Unauthorized use of these marks is strictly prohibited. 2014 Apr;24(4):428-33. doi: 10.1016/j.numecd.2013.08.012. The effects of aspirin and fish oil consumption on lysophosphatidylcholines and lysophosphatidic acids and their correlates with platelet aggregation in adults with diabetes mellitus. Beta blockers achieve their effects by blocking the effects of the hormone adrenaline on receptors in your body called beta receptors; in turn, lowered response in these receptors leads to lower heart stress and, consequently, lower pressure in your blood vessels. Yes, with care: Using fish oil along with Prinivil (lisinopril) and Aspirin is usually safe. Four subjects were given 37.5 mg aspirin orally, and 6 weeks later they received a natural, stable fish oil daily for 1 week before taking the same single dose of aspirin. 2021 Feb 27;22(5):2394. doi: 10.3390/ijms22052394. When red rice is fermented with certain strains of yeast, it creates a very low-dose statin. The first tested daily low-dose aspirin, which helps thin the blood and has been shown to reduce risk for heart events. How long does it take for omega-3s to work? One of the problems is that the cause and effect are not immediate. There is evidence to indicate that fish oil may support eye health. BMC Nephrol. A single study known as REDUCE-IT showed the benefit of a specific type of fish oil. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Aspirin has blood thinning properties similar to those found in medications called anticoagulants, which slow the normal clotting of your blood. The site is secure. Vitamins often have dyes in them that can discolor Dr. Michael Kleerekoper and another doctor agree. Taking fish oil supplements with meals or freezing them can reduce these issues. Effect of dietary FO and aspirin (ASA) treatment on serum lipids in mice., Effect of FO plus aspirin (ASA) on BP . 8600 Rockville Pike Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model. Dr. Pamela Pappas answered. Which is better fish oil or aspirin? There is no data for Aspirin for primary prevention (before you have heart diseas or just take a tablespoonful of olive oil daily. Thank you for watching. This 4% number is significantly lower than we would expect to find in the general population who were at risk for heart events. Over-the-counter supplements arent regulated for quality and contents, so you dont know what youre really getting. The American College of Cardiology completed their 2021 scientific sessions, where many research teams presented trial results. Omega-3 fatty acids can be acquired by eating cold water fish such as: Tuna Salmon Halibut Mackerel Sardines Herring Anchovies Rainbow trout "The American Heart Association (AHA) recommends eating a three-ounce serving of oily fish at least two times a week to get the heart-healthy benefits from omega-3s," says Dodson. Related Questions. 2011 Aug;4(4):270-2. doi: 10.1093/ndtplus/sfr046. ALA or alpha-linolenic acid is another type of omega-3 found in plants sources such as nuts and seeds. Garlic oil capsules vs low dose aspirin - which is more effective? 1991 Oct;44(2):123-6. doi: 10.1016/0952-3278(91)90195-b. Dr. Steve Nissen, cardiologist and Chief Academic Officer, Heart, Vascular & Thoracic Institute, presents the summaries of three trials answering the following questions: Left Atrial Appendage Occlusion Study (LAAOS III): If you have atrial fibrillation and undergoing heart surgery should you have your left atrial appendage (LAA) closed during surgery? All rights reserved. 1991 Dec;84(6):2286-93. doi: 10.1161/01.cir.84.6.2286. Diets and Cellular-Derived Microparticles: Weighing a Plausible Link With Cerebral Small Vessel Disease. In a similar study conducted by researchers from Oxford, 15,480 type 1 and 2 diabetics were monitored for 7 and a half years and it was found that those who took Aspirin had a lower risk of CV events but this was equally offset by more cases of serious bleeds. While Aspirin is also anti-inflammatory, it can create a lot of damage in your stomach and brain, which the FDA is discovering. struggling to manage it, you might consider reaching for supplements or The first tested daily low-dose aspirin, which helps thin the blood and has been shown to reduce risk for heart events. it interacted with risperidone. Finding the one that works for you is a better route than taking a supplement to try to counteract ill effects of your current prescription. CIHR-CCI117951/Canadian Institutes of Health Research/Canada. Epub 2013 Dec 18. Lemon water may help reduce some symptoms of arthritis when consumed alongside your normal medicine routine. Beta blockers are a class of medications commonly used to treat cases of high blood pressure. To be safe, split them up by at least two hours. According to authors, this risk cancels out the potential benefits. The .gov means its official. So you can say, Ive been taking Aspirin for years without any problems. But, this is like telling me you have been smoking for years without getting lung cancer. Murphy KJ, Galvin K, Kiely M, Morrissey PA, Mann NJ, Sinclair AJ. 2014 The British Pharmacological Society. But it may take 6 weeks to 6 months to see a significant change in mood, pain, or other symptoms. After following participants for an average of 7.4 years, researchers found no significant difference in heart events among adults taking fish oil versus placebo. In one of them, cardiac surgeons looked at the effect of occluding, that is, stitching together the appendage on the left atrium, one of the upper chambers of the heart, at the time of cardiac surgery. Background and purpose: Conclusions and implications: Fish oil is a natural anticoagulant, which means it can prevent the blood from clotting. FO alone, but not aspirin, attenuated arterial neointimal growth in response to injury. It very much depends upon other factors that change from individual to individual and, in particular, your past and present health status. The blood thinner rivaroxaban is as safe as aspirin, and more effective at preventing recurrence of life-threatening blood clots in the legs and lungs, according to a new study. Applies to: aspirin and Fish Oil (omega-3 polyunsaturated fatty acids) Talk to your doctor before using omega-3 polyunsaturated fatty acids together with aspirin. is one of those medications interacting? Leukotriene B(4)was increased by 19% (P<0.05) after aspirin, and decreased by 69% (P<0.05) after fish oil + aspirin. A heart attack occurs when blood flow to your heart is cut off. A Cleveland Clinic podcast to help you learn more about heart and vascular disease and conditions affecting your chest. Analysis of the effects of a combination of aspirin and n-3 fatty acids on the eicosanoid profile. No solid evidence supports benefits of taking CoQ10 supplementation while taking statins, Martin says. Not all fish oil supplements are the same, so there are a few key things to look for when shopping for fish oil brands. Add your drug list to My Med List to view medical information in a simple, easy-to-read, personalized format. Cardiovascular disease, including heart disease and stroke, affects tens of millions of people in the United States. (A), Protective effect of dietary FO plus aspirin against thrombus formation in vivo ., Effect of dietary FO and aspirin (ASA) on TxA 2 metabolite ( TxM), Effect of dietary FO plus aspirin (ASA) on vascular remodelling in response to, Synergistic effect of dietary FO and aspirin (ASA) on perivascular inflammatory cell infiltration, Effect of dietary FO and aspirin (ASA) on early recruitment of inflammatory cells, Effect of dietary FO and aspirin (ASA) on mRNA expression of anti and, Effect of dietary FO and aspirin (ASA) on the expression of adhesion molecules, Detection of r esolvin E 1 in plasma of aspirin (ASA), FO ,, MeSH Mottola G, Werlin EC, Wu B, Chen M, Chatterjee A, Schaller MS, Conte MS. Prostaglandins Other Lipid Mediat. 1989 Sep;80(3 Pt 1):I109-23. Fish oil could be your answer to fighting belly fat. We used corn oil, which doesn't do anything, and the REDUCE-IT trial used mineral oil. The Aspirin and fish oil both can thin your blood and cause bleeding issues during the procedures. What is better than fish oil for inflammation? The https:// ensures that you are connecting to the That said, splitting your supplement into two smaller doses in the morning and at night can reduce acid reflux. Providing essential fatty acids that are critically important to your dog and cat's overall health, pawTree's nutrient-rich Wild Alaskan Salmon Pollock Oil contains over 15 heart-healthy Omega-3 and Omega-6 Fatty Acids. Careers. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. To be clear I am a bigger fan of animal-based Omega 3s such as fish or krill oil, which offer EPA/DHA, as opposed to the plant-based Omega 3. Serum thromboxane A(2)was decreased by 40% (P<0.05) after aspirin alone, but by 62% (P<0.01) after fish oil + aspirin. Seth Martin, M.D., M.H.S When cholesterol and other substances build up on your artery walls, they create something called plaque, which narrows the passageways and restricts blood flow. FO or aspirin alone inhibited platelet aggregation; however, when combined, they exhibited synergistic suppression of platelet activity in mice, independent of COX-1 inhibition. eCollection 2021. Kincardine Times is an independently owned & operated division of Canadian Community News. Read More. However, this does not necessarily mean no interactions exist. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Available for Android and iOS devices. Fish oil and gingko biloba. To view an interaction report containing 4 (or more) medications, please sign in or create an account. We explore prevention, diagnostic tests, medical and surgical treatments, new innovations and more. Usually avoid combinations; use it only under special circumstances. official website and that any information you provide is encrypted I had a mild allergic reaction to fexofenadine a couple of weeks ago. Bethesda, MD 20894, Web Policies It is unlikely that you have heart disease. But you should think twice before you do If you have any kind of heart issues, please talk with your physician before making any health changes. A drug made from a highly purified form of EPA (an omega-3 fatty acid found in fish) appears to help reduce plaque in the heart's arteries, according to a study published online Aug. 29, 2020, by the European Heart Journal. Pcp has me taking 3 krill oil pills daily due to low omega 3's. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other abusable medications. What is your opinion on a supplement called Omega XL by Great Healthworks. We are vaccinating all eligible patients. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Prostaglandins Leukot Essent Fatty Acids. Based on both studies, authors do not recommend fish oil or low-dose aspirin for heart disease prevention in healthy, diabetic adults.Although fish oil supplements carry little to no risks, aspirin actually could increase risk of serious complications in otherwise healthy individuals. The problem was that aspirin also appeared to increase major bleeding events, which is a known side effect of blood thinners like aspirin. When taken by mouth: Fish oil is likely safe for most people in doses of 3 grams or less daily. Due to these potential benefits, fish oil has become a popular dietary . Dr. Thaddeus Gala encourages you to make your own health care decisions based upon your research and talk to your health care provider before making lifestyle changes. and transmitted securely. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. Steven Nissen, MD: Nutr Metab Cardiovasc Dis. Copyright 2014 Dr. Thaddeus Gala, DC. No alcohol/food interactions were found. Is it safe to take fish oil supplements with a low dose aspirin daily? But it may take, Because most of the benefits of fish oil are associated with long-term use, you can take it at. Prevention of occlusive arterial thrombus formation by a single loading dose of prasugrel suppresses neointimal hyperplasia in mice. If youre facing an increased risk for high cholesterol and youre a Following the protocol amendment in 2011, participants unable to discontinue aspirin use were eligible for randomization to fish oil or matching placebo with continuation of open-label aspirin use.. b Number of participants whose primary outcome was determined by imputation; fish oil n = 62 (23%), placebo n = 60 (23%).. AVF indicates arteriovenous fistula. Algae oil and flaxseed oil, which contain different types of omega 3 fatty acids, have been linked to health benefits. Use of aspirin with beta-blockers can also potentially cause problems. Clipboard, Search History, and several other advanced features are temporarily unavailable. sharing sensitive information, make sure youre on a federal A possible alternative to fish oil, krill oil boasts omega-3 fatty acids that may help improve heart health, fight inflammation and support brain and nervous system health. Email this report to a friend, doctor, or patient. Blood samples for determination of whole blood p It is made up of omega-3 fatty acids which contain anti-inflammatory properties. Connect with a U.S. board-certified doctor by text or video anytime, anywhere. For these, please consult a doctor (virtually or in person). The site is secure. The biggest distinction is that omega-3 is a nutrient, whereas fish oil is one source of that nutrient. National Library of Medicine Commonly used ACE inhibitors include catopril, lisinopril, benazepril and fosinopril. Omega-3 therapy with prescription fish oil can reduce triglycerides by 30 to 50 percent in those with levels that are at 500 mg/dL or more, and who are at an increased risk of gettingpancreatitis. After an average follow-up of 7.4 years, researchers found that adults taking aspirin had 12% lower risk of heart attack, stroke and heart-related death than those taking the placebo. When it came to aspirin, however, findings were slightly different. official website and that any information you provide is encrypted Other medications that can trigger undesired effects in combination with fish oil include birth control pills and the fat absorption blocker orlistat. Taking more than 3 grams daily might increase the chance of bleeding. Both low dose aspirin and fish oil reduce risk of blood clots. Int J Mol Sci. Fatty acids and TxA(2) generation, in the absence of platelet-COX-1 activity. Home, Advertising & Sponsorship Policy. Commonly used anticoagulants include heparin, clopidogrel and warfarin. that, says Over long periods, scientists say that omega-3 can reduce immune system function because it lowers the bodys inflammatory responses. Circulation. You can take a higher dose if you struggle with health issues such as diabetes, chronic pain, sleep apnea, fibromyalgia, neuropathy, or arthritis. The fish oil presumably helps with the circulation and health of the heart. Aspirin is commonly prescribed and recommended by most conventional physicians as a blood thinner for those at risk for heart attack, stroke, or aneurysms. The lower dose of aspirin seemed to work every bit as well as the higher dose of aspirin. Heart, Vascular & Thoracic Institute (Miller Family). From what i know, turmeric fish oil and beer do not cause blood thinning. HealthTap uses cookies to enhance your site experience and for analytics and advertising purposes. Now there's one other issue, and that is that both of these trials showed an increase of atrial fibrillation with fish oil. Fish oil gets to the root cause of inflammation. The typical recommendation is an 81 mg baby aspirin per day to keep . 2020 Jul 2;20(1):204. doi: 10.1186/s12906-020-02990-9. This is due to the anti-coagulant property of aspirin. Consult your doctor for more information on fish oil, aspirin and beta blockers. 2020 Feb;146:106401. doi: 10.1016/j.prostaglandins.2019.106401. HHS Vulnerability Disclosure, Help 1-ranked heart program in the United States. 2005 Apr 19;45(8):1295-301. doi: 10.1016/j.jacc.2005.01.045. Even worse is when a blood clot forms on a ruptured plaque and blocks the artery entirely, cutting off the flow of oxygen to part of your body. The latest information about heart & vascular disorders, treatments, tests and prevention from the No. Theres usually a major event like a heart attack or cancer in an x-ray. Abdolahi A, Georas SN, Brenna JT, Cai X, Thevenet-Morrison K, Phipps RP, Lawrence P, Mousa SA, Block RC. What is the difference between fish oil and omega-3? Pharmacodynamic interaction of naproxen with low-dose aspirin in healthy subjects. All rights Reserved. Federal government websites often end in .gov or .mil. That's the full-sized aspirin tablet. Specialized pro-resolving mediator network: an update on production and actions. The information on this website is not intended to replace your physician and is not intended as medical advice. This has become very controversial because many studies have showed no benefit of fish oil. A study came out involving people who took fish oil for 5-6 months. That means staying active, eating healthy, maintaining a healthy weight, and keeping blood sugar, blood pressure and cholesterol in check. Studies have shown some benefit for joint pain, but they are not conclusive. Consult your doctor before using aspirin with beta-blockers or fish oil. & Key Benefits: Natural Omega-3 Fatty Acids Dog . Although fish oil supplements carry little to no risks, aspirin actually could increase risk of serious complications in otherwise healthy individuals. Fish oil and aspirin taken together in pregnancy? 2017 Dec;5(Suppl 3):S30. In combination with beta-blockers or any other high blood pressure medication, use of fish oil can lower your blood pressure too far and endanger your health. Does daily low dose aspirin, fish oil, and turmeric coupled with a couple light beers thin the blood too much? There's something fishy about this bleeding. In this trial, 12,546 people (all of whom were deemed to be at moderate risk of a future heart event) were followed for 5 years and were given either an Aspirin (100mg a day) or a dummy pill, known as a placebo, daily. Blood samples for determination of whole blood production of eicosanoids were taken before and after each experimental period. This is due to the anti-coagulant property of aspirin. Typically, you wouldnt get that kind of triglyceride lowering with over-the-counter supplements. Write CSS OR LESS and hit save. When it comes to Aspirin (or ASA or acetylsalicylic acid), we find that the growing body of information that we have accumulated continues to narrow the spectrum of just who will benefit by taking a low dose (defined as 81 or 80mg) every day. Both studies included nearly 15,500 people, half of who were randomly assigned to the active treatment while the other half received a placebo with no active ingredients. What can replace aspirin for blood thinner? The lower dose of aspirin seemed to work every bit as well as the higher dose of aspirin. Aspirin and beta-blockers are both used to treat or prevent problems related to your cardiovascular health. Should i take a baby aspirin everyday if i'm taking fish oil supplements? There is more research to be done. Now we presented the results of our study of fish oil. A better way to get omega-3 fatty acids is to eat fatty fish such as sardines, herring, albacore tuna, and salmon, among others. Moreover, its surprising to me that more people dont recognize the power of fish oil over Aspirin. Now this appendage is known to be associated with the formation of clot and, later on, a stroke. Research shows that you only convert 2-20% of plant-based Omega 3 into a form that your body can use. Bookshelf Minimally clinically significant. Summary Taking large amounts of fish oil can inhibit blood clot formation, which may increase the risk of bleeding and cause symptoms such as nosebleeds or bleeding gums. Anticoagulants achieve their effects by reducing the "stickiness" of components in your blood called platelets, which normally clump together and form beneficial clots that stop your blood flow when you bleed. Based on both studies, authors do not recommend fish oil or low-dose aspirin for heart disease prevention in healthy, diabetic adults.Although fish oil supplements carry little to no risks, aspirin actually could increase risk of serious complications in otherwise healthy individuals. Like what you heard, subscribe wherever you get your podcasts or listen at clevelandclinic.org/loveyourheartpodcast. There are several different statin drugs and they can be given at various doses. Beta blockers are a class of medications commonly used to treat cases of high blood pressure. Femoral arterial remodelling was induced by wire injury in mice. According to authors, findings add to a body of evidence questioning the use of fatty acids to prevent heart events. Fish oil contains two omega-3 fatty acids called docosahexaenoic acid, or DHA, and eicosapentaenoic acid, or EPA. Omega-3 supplements can ma. Secondly, despite the fact that both of these have been around for seemingly forever (Aspirin is now more than a century old), new research has continued to change the answers we provide despite the passage of all this time. Epub 2010 Oct 28. Whole blood production of thromboxane, prostacyclin and leukotriene B4 after dietary fish oil supplementation in man: effect of vitamin E. Low dose supplementation with two different marine oils does not reduce pro-inflammatory eicosanoids and cytokines in vivo. No warnings were found for your selected drugs. We comply with the HONcode standard for trustworthy health information. Although aspirin (acetylsalicylic acid) is commonly used to prevent ischaemic events in patients with coronary artery disease, many patients fail to respond to aspirin treatment. However, when treating high triglycerides, your doctor may recommend up to 15 grams if you have high blood pressure and as much as 10 grams if you have rheumatoid arthritis. Fish Oil is the Better Option The statement above is telling us that if you have not had a previous heart condition, Aspirin is not a good primary form of prevention. Studies: Fish oil has been extensively studied for dozens of inflammatory and autoimmune disorders. Omega-3s may increase bleeding risk when a person takes them with specific anticoagulant or medication. Top answers from doctors based on your search: Created for people with ongoing healthcare needs but benefits everyone. Garlic oil capsules vs low dose aspirin - which is more effective? Fish oil contains active ingredients called omega-3 fatty acids, which appear to moderately lower your blood pressure by widening the interior of your blood vessels. Two main omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are found mainly in fish and fish oil. Before The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Fish oil supplements and low-dose aspirin are not recommended for the prevention of heart disease in healthy diabetic adults, based on results of a UK study which found no clear benefit of either treatment in reducing heart events.