Microcrystalline Cellulose NF. <> Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. B;vLZpHU%ChUyD+[ They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Request media, explore upcoming events and read our latest updates. Go to Investor Relations. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Terms and Conditions Compliance Solutions Industries About 3E News & Events . We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. /Type/Page They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" 1 0 obj << PDF (28.38 mb) 2022 Corporate Fact Sheet. . 4 0 obj Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Learn about FMC's industry leading goal of net-zero emissions by 2035. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Production of Pharmaceutical Grade Microcrystalline Cellulose. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. If breathing is difficult or if . We respect your privacy FMC Privacy Policy. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O Powder becomes slippery when wet. BIOACCUMULATIVE POTENTIAL These grades have particle sizes ranging from <30 to approximately 200. If you are already a ChemPoint customer then sign up for access to our online ordering website. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. However, consumption of large quantities of the material may have a laxative effect. : 160182 Date Approved: 05/25/2010 Revision No. Van Veen, G.K. Bolhuis, Y.S. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. However, if handling bulk powders, observance of appropriate safeguards is recommended. A family of polysaccharide products that allow distinctive drug delivery solutions. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. stream FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . This Microcrystalline Cellulose . }o]X4]. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. . It is also inert and biocompatible. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? Doses up to 30 g per day appear to be . Have an order or account question? Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. Page 1 of 8. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. . q9;v80q>jZ Microcrystalline Cellulose; Cellulose; Functions. endobj % Molecular weight: Not Applicable 1.5. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. It is available in different grades and particle sizes. Quantity: 1 700 kgs. FMC, JRS and Mingtai were estimated to hold for . Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no ( Microcrystalline cellulose is a commonly used excipient in the . Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . It is also used in plaque assays for counting. cas:9000-11-7 msds Carboxymethyl cellulose. Find answers in our support articles. };khd5x=fr ( The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Avicel RC-591 & CL-611 - Description. SDS. endobj TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. No. Instead, they obtained a stable colloidal suspension. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. endobj < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. 2008-2023 ChemPoint. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. X\o^ *r_ *?~4$ &0Y# 2021 Annual Report. 4 0 obj The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. CAS No. Are you sure you want to delete your template? In large quantities it provides dietary bulk and may lead to a laxative effect. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. q9;v80 MCC helps in the formation of spheres because of its . PharmaCentral 2021 . Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. No. There have always been two different points of view for the liquidity of MCC. Unique functionality for a broad range of pharmaceutical applications. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. CoA. ChemicalBook. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Avicel Microcrystalline Cellulose: Chemical Identifiers. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Product Name: Microcrystalline Cellulose 1.2. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . } !1AQa"q2#BR$3br <> MSDS Ref. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. EMCOCEL 90 M. 130. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. Looking for FMC'searnings news? <> Earth Supplied Products LLC. Heavy metals, % NMT 0.001 lH5JWy}DgKRR"Fs Delivering efficient and robust formulations. SUBSTANCE IDENTIFICATION 1.1. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. % For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. 51395-75-6 Avicel RC 591. (1962). Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Battista, O. Product Name: Microcrystalline Cellulose E460 1.2. xv}O2' H~KEe9>G/,:9\i Truly distinctive drug delivery solutions. /Resources 2 0 R We are artists at heart and creators by nature. The table below shows the most common physicochemical parameters of this raw material. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . SCMm_>x^O9l (n. CAS 9004-34-6. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * Microcrystalline cellulose (C6H10O5)n is refined wood pulp. The aqueous solution to barrier membrane coating. The short-term limit for total inhalable dust is 20 mg/m3. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Origin(s): Plant/Botanical. . Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. Cellulose microcrystalline for column chromatography. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. 8 0 obj Alginates also function as actives in some anti-reflux products. There may be more fiber in your food than you realized.